A review on decreased calcium and vitamin b12 absorption with long term proton pump inhibitor therapy

Proton pump inhibitors (PPI) are now one of the most widely used classes drugs. PPIs have proven to a very favorable safety profile and it is unusual for patient stop these drugs because side effects. However, increasing numbers patients chronically taking gastro esophageal reflux disease number other common persistent conditions, therefore long-term potential adverse effects receiving attention. Nowadays as PPI main peptic ulcer GERD ,a part from this they also preferred in drug induced gastric irritation .In article studies systematically examined, well chronic usage on VB12 calcium , absorption which leads neurologic disorders osteoporosis. In general each three areas led differing conclusions, but when examined systematically, showing consistent results that support conclusion processes can important clinical implications.